0097 Sleep and Eating Rhythms are Associated with Metabolic Risk in Postmenopausal Women

Abstract Introduction Postmenopausal women are particularly vulnerable to metabolic dysfunction. Compelling evidence suggests that this is due their lacking the protective effect of estrogens. We have shown circulating estrogens regulate daily eating and sleep-activity rhythms in female mice protect them from obesity diabetes. However, few studies investigated whether postmenopausal disrupted could contribute The purpose study was investigate relationship between rhythms, sleep, risk women. Methods During 7 days, we studied sedentary, who were not taking hormones (estrogens ± progestin) metabolically unhealthy, defined as prediabetic or normal glucose tolerance with at least 1 feature syndrome. Women medications affecting sleep excluded. Sleep timing quality assessed by actigraphy logs. Times first last meals collected participants a texting system. Body composition (DXA), body mass index (BMI), waist circumference markers obesity. Lipid metabolism glycemic control fasting lipid panel HbA1c well oral test. Results Eighteen (mean SEM; 57.2 1.1 years) participated study. Both associated Specifically, later onset meal greater BMI fat percentage. Increased fragmentation reduced HDL. In addition, both duration worse measures. Longer larger circumference. Later time BMI. Conclusion found late poor long duration, These data suggest interventions reduce advance may improve Support (if any) This supported NIH awards R01DK124774, T32 AG078110, UL1TR001998.